From the FDA Drug Label
DRUG INTERACTIONS Drug Interference with Laboratory Tests: Alkaline Phosphatase (ALP) is used as a detection reagent in many laboratory tests and the presence of asfotase alfa in clinical laboratory samples could result in erroneous test results. Serum Alkaline Phosphatase: Serum ALP measurements are expected to be elevated during treatment and may be unreliable for clinical decision making. (7.1)
The provided text does not discuss using enzyme supplementation to account for low ALP levels. It mentions that asfotase alfa treatment can lead to elevated ALP measurements, but it does not address low ALP levels or how enzyme supplementation might affect them 1.
- Key point: The text discusses the impact of asfotase alfa on ALP measurements, making them unreliable for clinical decision making.
- Main idea: There is no information provided about using enzyme supplementation to address low ALP levels.
From the Research
Enzyme supplementation is not a recommended treatment for low Alkaline Phosphatase (ALP) levels, as it does not directly address the underlying cause of the condition. Low ALP levels, also known as hypophosphatasia, are typically caused by genetic mutations affecting ALP production or function, and may also be related to malnutrition, certain medications, or other medical conditions 2. The most recent and highest quality study on this topic, published in 2025, found that treatment with asfotase alfa, a bone-targeted enzyme replacement therapy, can improve physical functions, non-skeletal symptoms, and quality of life in patients with hypophosphatasia, regardless of age or time of disease onset 3.
Key Points to Consider
- Low ALP levels can be caused by genetic disorders, malnutrition, certain medications, or other medical conditions
- Enzyme supplementation is not a recommended treatment for low ALP levels
- Asfotase alfa, a bone-targeted enzyme replacement therapy, can improve physical functions, non-skeletal symptoms, and quality of life in patients with hypophosphatasia
- Treatment should focus on addressing the underlying cause of low ALP levels, rather than directly supplementing the enzyme itself
Recommendations for Management
- Consult with a healthcare provider to determine the underlying cause of low ALP levels
- Consider specific nutrient supplementation, such as zinc, magnesium, or vitamin B6, if malnutrition is suspected
- Medication adjustments or other targeted treatments may be recommended based on the specific cause of low ALP levels
- Asfotase alfa may be considered as a treatment option for patients with hypophosphatasia, under the guidance of a healthcare provider 3.