What two active agents are combined in the medication Synjardy?

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Last updated: November 2, 2026 • View editorial policy

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Synjardy Contains Empagliflozin and Metformin

Synjardy is a fixed-dose combination tablet containing empagliflozin (an SGLT2 inhibitor) and metformin hydrochloride (a biguanide). 1

Medication Components

Empagliflozin

  • Mechanism: SGLT2 inhibitor that reduces renal glucose reabsorption, increasing urinary glucose excretion 1
  • Available doses in Synjardy: 5 mg, 10 mg, 12.5 mg, or 25 mg 1
  • Chemical formula: C23H27ClO7, molecular weight 450.91 1

Metformin Hydrochloride

  • Mechanism: Biguanide that decreases hepatic glucose production, reduces intestinal glucose absorption, and improves insulin sensitivity 1
  • Available doses in Synjardy: 500 mg or 1,000 mg (immediate-release or extended-release formulations) 1
  • Chemical formula: C4H11N5•HCl, molecular weight 165.63 1

Formulation Details

Synjardy (immediate-release) comes in four strengths:

  • 5 mg empagliflozin/500 mg metformin HCl
  • 5 mg empagliflozin/1,000 mg metformin HCl
  • 12.5 mg empagliflozin/500 mg metformin HCl
  • 12.5 mg empagliflozin/1,000 mg metformin HCl 1

Synjardy XR (extended-release) comes in four strengths:

  • 5 mg empagliflozin/1,000 mg metformin HCl
  • 10 mg empagliflozin/1,000 mg metformin HCl
  • 12.5 mg empagliflozin/1,000 mg metformin HCl
  • 25 mg empagliflozin/1,000 mg metformin HCl 1

The XR formulation consists of an extended-release metformin core coated with immediate-release empagliflozin 1.

References

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.