What is the first line of treatment for patients with Functional Neurological Disorders (FND)?

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Last updated: June 13, 2025View editorial policy

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From the Guidelines

The first line of treatment for patients with Functional Neurological Disorders (FND) should be a multidisciplinary approach that prioritizes education, explanation, and a biopsychosocial framework, as recommended by the most recent consensus guidelines 1. This approach begins with a clear, empathetic explanation to the patient that their symptoms are real but represent a problem with how the nervous system functions rather than structural damage.

Key Components of Treatment

  • Education about the diagnosis and symptoms
  • Rehabilitation within functional activity
  • Use of taught self-management strategies
  • Psychological interventions, such as cognitive behavioral therapy (CBT), to address underlying psychological factors, stress management, and coping strategies
  • Occupational therapy to help patients regain independence in daily activities
  • Speech therapy for those with functional speech disorders

Considerations for Treatment

  • Factors important for engagement with treatment include a reasonable degree of understanding and agreement with the diagnosis, and motivation and agreement to treatment 1
  • Circumstances that may suggest a guarded or poor prognosis include transient or highly variable symptoms, unresolved litigation related to symptoms, severe psychiatric comorbidity, and other severe FND symptoms 1

Medication Use

Medication is not typically the primary treatment for FND, but may be used to address comorbid conditions like depression or anxiety, with SSRIs such as sertraline or escitalopram often prescribed 1

Importance of Early Intervention

Early intervention is crucial, even in the presence of severe FND symptoms, to improve outcomes and reduce morbidity, mortality, and impact on quality of life 1

From the Research

Treatment Approaches for Functional Neurological Disorders (FND)

The first line of treatment for patients with Functional Neurological Disorders (FND) typically involves a multidisciplinary approach, including rehabilitative therapies and psychological therapies.

  • Rehabilitative interventions, such as physical therapy and occupational therapy, are often used to treat functional motor symptoms 2.
  • Psychotherapy is also an emerging evidence-based treatment across FND subtypes, including those with seizure-type symptoms 2.
  • The optimal timing of specific therapeutic interventions is crucial and should be patient-centered, emphasizing the importance of individualized treatment plans 3.

Role of Occupational Therapy in FND Management

Occupational therapy (OT) plays a significant role in the management of FND, particularly in addressing sensory processing difficulties and improving functional neurological symptoms.

  • OT can help patients with FND develop strategies to manage sensory modulation difficulties, which are common in this population 4.
  • The use of standardized assessments, such as the Adolescent/Adult Sensory Profile (AASP) and The Canadian Occupational Performance Measure (COPM), can aid in the development of individualized treatment plans 4.

Importance of Early Diagnosis and Treatment

Early diagnosis and access to evidence-based treatments are critical in promoting recovery for patients with FND.

  • Delayed diagnosis and treatment can lead to increased disability and reduced treatment response 2.
  • A positive and supportive approach to diagnosis, emphasizing the genuine and reversible nature of FND symptoms, can facilitate treatment engagement and improve outcomes 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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