What are the alternatives to glycerine (glycerin) suppositories for treating constipation in infants?

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Last updated: June 14, 2025View editorial policy

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From the Guidelines

For infants with constipation, alternatives to glycerin suppositories include dietary changes, such as adding a small amount of prune, apple, or pear juice, which contains sorbitol that can help increase the frequency and water content of stools 1. When considering alternatives to glycerin suppositories, it's essential to prioritize dietary changes and proper hydration.

  • For formula-fed babies, switching to a different formula or adding 1-2 ounces of prune, apple, or pear juice daily can help alleviate constipation, as the sorbitol in these juices can increase stool frequency and water content 1.
  • For breastfed babies, mothers can try adjusting their own diet by reducing constipating foods, which may help improve their baby's bowel movements.
  • Ensuring adequate fluid intake is also crucial, especially in hot weather or during illness.
  • Gentle physical techniques, such as belly massage in a clockwise direction or moving the baby's legs in a bicycling motion, can help stimulate bowel movements.
  • A warm bath may also relax the anal sphincter and help relieve constipation.
  • For older infants eating solids, increasing high-fiber foods like pureed prunes, pears, or peaches can help promote regular bowel movements. These approaches are generally preferred before using medications because they address the underlying causes of constipation rather than just providing temporary relief. If constipation persists despite these measures, it's essential to consult a pediatrician for further guidance and potential recommendation of osmotic laxatives like Miralax (polyethylene glycol) in appropriate doses for infants, under medical supervision.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Alternatives to Glycerine Suppositories

If glycerine suppositories are not available, there are other alternatives that can be used to treat constipation in infants.

  • Other types of suppositories, such as saline or soap suppositories, may be used as an alternative to glycerine suppositories 2, 3.
  • Enemas can also be used as an alternative to suppositories, and may be more effective in some cases 2, 3.
  • Dietary changes, such as increasing fluid intake or adding fiber to the infant's diet, may also help to relieve constipation.
  • In some cases, medications such as laxatives or stool softeners may be prescribed by a healthcare provider to help relieve constipation.

Important Considerations

When using any alternative to glycerine suppositories, it is essential to follow the instructions provided by a healthcare provider and to monitor the infant's response to treatment.

  • It is also crucial to note that the use of glycerine suppositories or enemas in premature infants has been associated with an increased risk of necrotizing enterocolitis, although the evidence is not conclusive 2, 3.
  • Therefore, any alternative treatment should be used with caution and under the guidance of a healthcare provider.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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