There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for ciprofloxacin (OTIC) do not address this question.
From the Research
Treatment Dosage of Ciprofloxacin for Otitis Media with Perforation
- The treatment dosage of ciprofloxacin for otitis media with perforation varies depending on the study and the specific treatment regimen.
- In one study, ciprofloxacin was administered orally at a dose of 250 mg twice a day for 5 to 10 days 1.
- In another study, ciprofloxacin was administered topically at a dose of 3 drops (250 micrograms/mL in saline solution) twice a day for 5 to 10 days 1.
- A study comparing oral ciprofloxacin with amoxycillin/clavulanic acid used a dose of 500 mg twice daily for 9 days 2.
- A community-based, multicentre, double-blind randomised controlled trial used ototopical ciprofloxacin (0.3%) 5 drops twice daily for 9 days 3.
Efficacy of Ciprofloxacin Treatment
- The efficacy of ciprofloxacin treatment for otitis media with perforation has been demonstrated in several studies, with high percentages of favorable clinical response and bacteriological eradication 1, 2, 3.
- One study found that topical ciprofloxacin was effective in curing chronic otitis media, even when caused by Pseudomonas 1.
- Another study found that ciprofloxacin was superior to amoxycillin/clavulanic acid in treating chronic otitis media 2.
- A study in Aboriginal children found that ototopical ciprofloxacin was effective in achieving cure for chronic suppurative otitis media 3.