From the Guidelines
The diagnostic criteria for Complex Regional Pain Syndrome (CRPS) are not explicitly stated in the provided evidence, which focuses on autoinflammatory diseases such as CAPS, TRAPS, MKD, and DIRA, rather than CRPS specifically. The provided evidence 1 discusses the monitoring of disease-specific symptoms and patient-related outcomes for various autoinflammatory diseases, including CAPS, but does not provide diagnostic criteria for CRPS. Key points to consider in diagnosing CRPS include:
- Persistent burning pain
- Sensitivity to touch
- Swelling
- Limited range of motion
- Changes in skin temperature and color
- Abnormal hair or nail growth However, these criteria are not mentioned in the provided evidence 1, which instead focuses on diseases such as CAPS, characterized by symptoms like fever, rash, and musculoskeletal symptoms. In clinical practice, diagnosing CRPS typically involves a combination of medical history, physical examination, and diagnostic tests to rule out other conditions, but the provided evidence does not support a specific set of diagnostic criteria for CRPS. Given the lack of direct evidence, the diagnosis of CRPS should be based on the most recent and highest-quality clinical guidelines available, which may include criteria such as the Budapest criteria.
From the Research
Diagnostic Criteria for Catastrophic Antiphospholipid Syndrome (CAPS)
The diagnostic criteria for CAPS include:
- Development of a thrombotic event of three or more organs in less than a week 2
- Presence of antiphospholipid antibodies, such as lupus anticoagulant (LA) and/or anticardiolipin antibody (aCL) and/or beta(2)-GPI antibodies 3, 2
- Microvascular thrombosis on histology 2
- High titer antiphospholipid antibodies 4, 3
Clinical Features of CAPS
Clinical features of CAPS include:
- Multiple organ involvement, such as cardiopulmonary, central nervous system, and renal system 3
- Thrombocytopenia, seen in more than 60% of cases 2
- Hemolytic anemia, such as micro-angiopathic hemolytic anemia (MHA) 4, 5
- High-grade fever, renal failure, hepatic dysfunction, and unconsciousness 5
Laboratory Criteria for CAPS
Laboratory criteria for CAPS include: