From the FDA Drug Label
DESCRIPTION Dextroamphetamine sulfate is the dextro isomer of the compound d,l-amphetamine sulfate, a sympathomimetic amine of the amphetamine group. Chemically, dextroamphetamine is d-alpha-methylphenethylamine, and is present in all forms of dextroamphetamine sulfate as the neutral sulfate. The answer is yes, Dextroamp-Amphet (dextroamphetamine) is the same as dextroamphetamine, as they refer to the same chemical compound, d-alpha-methylphenethylamine 1.
- The drug label explicitly states that dextroamphetamine is the dextro isomer of the compound d,l-amphetamine sulfate.
- There is no mention of "dextroamphetamine-ampethimine" in the provided drug label, suggesting that dextroamphetamine is the correct and recognized term for this compound 1.
From the Research
Dextroamp-Amphet is not exactly the same as dextroamphetamine, as it refers to a mixed amphetamine salt combination, whereas dextroamphetamine is a single isomer medication. The key difference between the two lies in their composition, with Dextroamp-Amphet typically containing a 3:1 ratio of dextroamphetamine to levoamphetamine, and dextroamphetamine containing only the dextro (right-handed) form of amphetamine. This distinction is crucial in clinical practice, as some patients may respond better to one formulation over the other, with the mixed salts often providing a smoother onset and longer duration of action for many people with ADHD, while pure dextroamphetamine may have fewer peripheral side effects for certain individuals, as noted in studies such as 2. Some of the benefits and differences between these medications are also discussed in the context of treating ADHD and other conditions in studies like 3, 4, and 5, although the most recent and highest quality evidence, such as 2, should be prioritized when making clinical decisions. In terms of safety, particularly regarding cardiovascular effects, medications like methylphenidate, amphetamines, and atomoxetine have been examined in studies like 6, but the focus remains on the specific comparison and choice between Dextroamp-Amphet and dextroamphetamine based on the most current evidence. The choice between these two should be guided by the most recent clinical evidence and patient-specific factors, prioritizing outcomes related to morbidity, mortality, and quality of life. Key points to consider include:
- The composition difference between Dextroamp-Amphet and dextroamphetamine
- The potential for different response profiles among patients
- The importance of prioritizing the most recent and highest quality evidence, such as 2, when making clinical decisions
- Considering patient-specific factors and potential side effects when choosing between these medications.