De Quervain's Tenosynovitis: This condition, which affects the tendons on the thumb side of the wrist, is a common cause of sharp, intermittent pain in this area, especially when forming a fist, grasping, or turning the wrist.

Wrist Ganglion Cyst: A common benign lump that can cause pain, especially if it presses on a nerve or tendon, often found on the thumb side of the wrist.
Scaphoid Fracture: A fracture of one of the small bones in the wrist, which can cause sharp pain, especially with movement or weight-bearing activities.
Thumb Carpometacarpal Joint Arthritis: Arthritis in the joint at the base of the thumb can cause sharp pains, especially with gripping or twisting motions.

Infectious Tenosynovitis: An infection within the tendon sheath, which can lead to severe consequences if not promptly treated with antibiotics.
Gout or Pseudogout: These conditions can cause sudden, severe pain and swelling, often affecting the wrist or thumb, and require specific treatment to manage symptoms and prevent long-term damage.
Radial Nerve Compression: Compression of the radial nerve can cause pain and weakness in the wrist and hand, and if not addressed, can lead to permanent nerve damage.

Kienböck's Disease: A rare condition where the blood supply to one of the bones in the wrist (the lunate) is interrupted, leading to its collapse and potentially causing wrist pain.
Giant Cell Tumor of the Tendon Sheath: A rare, benign tumor that can cause pain and swelling in the wrist, especially if it compresses nerves or tendons.
Sarcoidosis: A systemic disease that can cause inflammation and pain in various parts of the body, including the wrists, though wrist involvement is less common.