From the Research
Yes, Lyrica (pregabalin) can cause hypotension (low blood pressure) and dizziness as side effects. These effects are relatively common, with dizziness occurring in up to 31% of patients and hypotension in approximately 2-5% of individuals taking the medication. The most recent and highest quality study, a systematic review and meta-analysis published in 2021 1, evaluated the extent to which specific drug groups are associated with orthostatic hypotension (OH), but did not specifically mention Lyrica. However, another study from 2017 2 discussed the importance of identifying and managing OH in the clinical setting, and the potential for medications to contribute to this condition. Given the potential for Lyrica to cause hypotension and dizziness, it is essential for patients to be aware of these risks and take steps to minimize them, such as changing positions slowly and staying well-hydrated. Additionally, doctors should recommend a gradual dose titration starting at lower doses (such as 75mg twice daily) and slowly increasing as tolerated, especially for elderly patients or those taking other medications that lower blood pressure. These symptoms often improve as the body adjusts to the medication over time, but patients should report persistent or severe dizziness to their healthcare provider. Some key points to consider include:
- The risk of hypotension and dizziness is higher when starting treatment or increasing the dose
- Elderly patients and those taking other medications that lower blood pressure may be at higher risk for these effects
- Patients should change positions slowly, especially when moving from lying to standing, and stay well-hydrated to minimize these side effects
- The symptoms often improve as the body adjusts to the medication over time, but patients should report persistent or severe dizziness to their healthcare provider.