What are the treatment options for androgenetic alopecia (male baldness)?

From the Guidelines

Treatment for male baldness, also known as androgenetic alopecia, should prioritize the use of platelet-rich fibrin (PRF) as a safe, easy, time, and cost-effective modality, particularly in mild cases, as it has shown promising results in managing the condition 1. The treatment options for androgenetic alopecia include both medications and procedures. The two FDA-approved medications are minoxidil (Rogaine) and finasteride (Propecia). Minoxidil works by prolonging the growth phase of hair follicles and increasing blood flow to the scalp, while finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT), which is responsible for miniaturizing hair follicles. Some key points to consider when treating androgenetic alopecia include:

• The use of PRF has been shown to be a valuable treatment option, particularly in mild cases 1
• PRP injections have also been used to treat androgenetic alopecia, with studies showing a significant increase in hair density and thickness 1
• Combination therapy using multiple approaches, such as minoxidil and PRP, often yields better results than single treatments alone 1
• Hair transplantation surgery and low-level laser therapy devices are also available options for more advanced hair loss It's essential to have realistic expectations, as these treatments typically slow or partially reverse hair loss rather than completely restoring hair. The choice of treatment should be based on the individual's specific needs and circumstances, and a healthcare professional should be consulted to determine the best course of treatment. Some of the benefits of using PRF include its safety, ease of use, and cost-effectiveness, making it a promising option for managing androgenetic alopecia 1.

From the FDA Drug Label

Minoxidil topical solution 5% is a clear, light amber liquid medication containing 5% minoxidil for use only on the scalp to help regrow hair in men. Minoxidil topical solution 5% is for use only by men Minoxidil topical solution 5% may be appropriate for you if you are a male at least 18 years old and experiencing gradually thinning hair or gradual hair loss on the top of the scalp (vertex only, as shown). The amount of hair regrowth is different for each person. Not everyone will respond to minoxidil topical solution 5%. Results may be seen as early as 2 months with twice daily use. For some men, it may take at least 4 months for results to be seen

Treatment Options for Androgenetic Alopecia (Male Baldness):

• Minoxidil (TOP): Minoxidil topical solution 5% is used to help regrow hair in men with androgenetic alopecia.
• Finasteride (PO): Although the provided finasteride drug label does not directly address its use for androgenetic alopecia, it is known to be used for this condition. However, this information is not present in the given drug label.

Based on the provided drug labels, minoxidil topical solution 5% is a treatment option for androgenetic alopecia (male baldness) in men with gradually thinning hair or gradual hair loss on the top of the scalp. Results may be seen as early as 2 months with twice daily use. 2

From the Research

Treatment Options for Androgenetic Alopecia

The treatment options for androgenetic alopecia, also known as male baldness, include:

• Medical treatments:
  • Topical minoxidil solution (2-5%) 3, 4, 5, 6, 7
  • Oral finasteride (1mg) 3, 4, 5, 6, 7
  • Oral dutasteride 5
• Low-level laser light therapy 3, 4, 5
• Hair transplantation 4, 6, 7
• Regenerative medicines:
  • Autologous platelet-rich plasma (PRP) 5, 7
  • Adipose-derived stem cells 5
  • Micrograft generation 5
  • Exosome treatments 4, 5
• Nutraceuticals and hormonal therapies 4

Efficacy and Safety of Treatments

The efficacy and safety of these treatments have been assessed in various studies, with topical minoxidil and oral finasteride being the most well-established treatments for androgenetic alopecia 3, 6. Low-level laser light therapy has also been shown to be effective in promoting hair growth 3. Hair transplantation is a surgical option for those who have failed medical treatment 6, 7.

Considerations for Treatment Selection

When selecting a treatment for androgenetic alopecia, considerations should include:

• Efficacy and safety of the treatment 4, 6
• Patient compliance and practicality of treatment 4
• Cost and financial considerations 4
• Individual patient needs and aesthetic goals 4
• Potential side effects and risks associated with each treatment 4, 6