How can I increase the concentration of Vyvanse (lisdexamfetamine)?

From the Guidelines

I strongly advise against attempting to increase the concentration of Vyvanse (lisdexamfetamine) beyond prescribed dosages, as this can lead to serious health risks and is potentially illegal. To adjust the dosage of Vyvanse, it is crucial to follow the guidance provided by a healthcare professional. According to the study published in the American Journal of Obstetrics and Gynecology in 2024 1, the usual starting dose of lisdexamfetamine is 20-30 mg orally every morning, and the dosage can be increased by 10 mg weekly to a maximum of 70 mg daily.

Key Considerations

• The dosage of Vyvanse should be tailored to individual needs and medical history.
• Increasing the dosage beyond the prescribed amount can lead to severe side effects, including cardiovascular issues, psychiatric problems, and a risk of dependence.
• Any adjustments to the medication regimen should be made under the supervision of a healthcare provider.

Alternatives to Consider

• If the current dose of Vyvanse is not effective, the healthcare provider may consider adjusting the timing of doses or switching to a different medication.
• Complementary treatments may also be explored to enhance the efficacy of the current medication regimen. It is essential to prioritize patient safety and adhere to the prescribed dosage and treatment plan to minimize the risk of adverse effects and ensure the best possible outcomes in terms of morbidity, mortality, and quality of life.

From the FDA Drug Label

The FDA drug label does not answer the question.

From the Research

Increasing Concentration of Vyvanse

To increase the concentration of Vyvanse (lisdexamfetamine), consider the following points:

• The concentration of Vyvanse is not typically something that can be increased by the user, as it is a pharmaceutical product with a standardized formulation 2, 3, 4, 5.
• Lisdexamfetamine is a prodrug that is hydrolyzed to its active form, d-amphetamine, in the blood following oral administration 2, 3, 4, 5.
• The efficacy of lisdexamfetamine has been demonstrated in several studies, with significant improvements noted in ADHD rating scales and assessments of executive function 2, 3, 4, 5.
• The safety profile of lisdexamfetamine is consistent with long-acting stimulants, with most adverse events being mild to moderate in severity 2, 3, 4, 5.

Factors Affecting Concentration

Some factors that may affect the concentration of Vyvanse include:

• Dose: The dose of lisdexamfetamine can affect its concentration in the body, with higher doses resulting in higher concentrations 3, 6.
• Administration: The method of administration, such as oral ingestion, can affect the concentration of lisdexamfetamine in the body 4, 5.
• Metabolism: The rate of hydrolysis of lisdexamfetamine to its active form, d-amphetamine, can affect its concentration in the body 2, 3, 4, 5.

Clinical Use

In clinical practice, the concentration of Vyvanse is not typically a concern, as the medication is prescribed and dispensed in a standardized formulation 2, 3, 4, 5. However, healthcare providers may consider the following when prescribing lisdexamfetamine:

• Patient response: The patient's response to lisdexamfetamine, including its efficacy and safety, can affect the prescribed dose and concentration 2, 3, 4, 5.
• Medical history: The patient's medical history, including any history of substance abuse, can affect the prescribed dose and concentration of lisdexamfetamine 6.