From the Research
The equivalent dose of lisinopril for losartan 25mg is approximately 10mg, as supported by the most recent and highest quality study available 1. When switching between these medications, lisinopril 10mg daily would provide similar blood pressure lowering effects to losartan 25mg daily. These medications work differently but achieve similar outcomes - lisinopril directly inhibits the angiotensin-converting enzyme, while losartan blocks angiotensin II receptors. Some key points to consider when transitioning between these medications include:
- Monitoring blood pressure closely as individual responses may vary
- The full antihypertensive effect may take 2-4 weeks to develop with either medication
- Patients should be aware that while these medications are therapeutically similar, side effect profiles differ slightly - ACE inhibitors like lisinopril are more commonly associated with dry cough compared to ARBs like losartan
- Kidney function and potassium levels should be checked within 1-2 weeks after switching, particularly in patients with renal impairment or those taking potassium supplements or potassium-sparing diuretics. It's also worth noting that the choice between lisinopril and losartan may depend on individual patient factors, such as comorbidities and potential drug interactions, as highlighted in studies such as 2 and 3. However, in terms of equivalent dosing, lisinopril 10mg is the most appropriate equivalent to losartan 25mg, based on the available evidence 1.