Does Eliquis Cause Drowsiness?
No, Eliquis (apixaban) does not cause drowsiness as a recognized side effect. Drowsiness is not listed among the adverse effects in the FDA-approved medication guide or prescribing information 1.
What Side Effects Should You Expect?
The FDA labeling for Eliquis clearly outlines the important side effects to monitor, and drowsiness is notably absent from this list 1. The primary concerns with Eliquis are:
Main Side Effects to Watch For:
Bleeding complications (the most important risk)
- Easy bruising
- Prolonged bleeding from cuts
- Nosebleeds
- Unusual bleeding from gums
- Heavy menstrual bleeding
- Blood in urine (red, pink, or brown)
- Black or tarry stools
- Coughing up blood
Allergic reactions
- Chest pain or tightness
- Swelling of face or tongue
- Trouble breathing or wheezing
- Feeling dizzy or faint 1
Important Caveat: Neurological Symptoms Are Possible
While drowsiness is not a typical side effect, one case report documented reversible neurological symptoms in an 80-year-old woman taking apixaban, including confusion, disorientation, headache, dizziness, and asthenia (weakness/fatigue) 2. These symptoms resolved within 72 hours of stopping the medication, and the patient had apixaban levels 4 times higher than normal. This occurred in a patient with advanced age, which may have contributed to drug accumulation 2.
When Neurological Symptoms Might Occur:
- Advanced age (≥80 years)
- Chronic kidney disease (reduced drug clearance)
- Drug accumulation leading to supratherapeutic levels 2, 3
If you're experiencing unusual fatigue, confusion, or feeling "off" while taking Eliquis, particularly if you're elderly or have kidney problems, contact your physician. These are not typical side effects but warrant evaluation, especially to check for bleeding complications (which can cause weakness) or drug accumulation 2.
Bottom Line
Drowsiness is not a recognized side effect of Eliquis based on FDA labeling and clinical guidelines 1. If you're experiencing drowsiness or unusual fatigue while taking this medication, discuss it with your doctor to rule out other causes, including bleeding complications or drug interactions with other medications you may be taking.