What are the corpora amylosa (corpora amylacea)?

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Dainyal Siddiqui, MD

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Manuel Jimenez, MD

Cardiology

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Franz Pierre-Louis, MD

Infectious Disease

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Last updated: February 25, 2025 • View editorial policy

From the Research

Corpora amylacea are waste containers created by specific cells that sequester waste products and foreign products, and assemble them within a glycan structure, and should be referred to as "wasteosomes" to avoid ambiguity. The concept of corpora amylacea has been studied extensively, with research dating back to the early 2000s [ 1 ]. Some key points about corpora amylacea include:

  • They are glycoprotein-based depositions that accumulate in the human body throughout aging [ 2 ]
  • They have been found in proximity to ventricular walls, pial surfaces, and blood vessels in the cerebrum [ 3 ]
  • They can be intracellular or extracellular structures, and their function and significance have not yet been fully identified [ 1 ]
  • Recent studies have proposed that corpora amylacea are waste containers created by specific cells, which sequester waste products and foreign products, and assemble them within a glycan structure [ 1 ]
  • The term "wasteosomes" has been proposed to refer to corpora amylacea, to avoid ambiguity and emphasize the waste products they entrap [ 1 ] It's worth noting that the most recent and highest quality study [ 1 ] provides the most comprehensive understanding of corpora amylacea, and their proposed function as waste containers. Some other studies have investigated the distribution and morphology of corpora amylacea in the human brain [ 2 ], [ 3 ], and the presence of S100 proteins in corpora amylacea [ 4 ]. However, the study by [ 1 ] provides the most recent and comprehensive understanding of corpora amylacea, and their proposed function as waste containers.

References

2
Research

Corpora amylacea in the brain form highly branched three-dimensional lattices.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2014

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