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Last updated: June 16, 2025View editorial policy

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Differential Diagnosis for Outgrowth on Eyelids

  • Single most likely diagnosis
    • Blepharitis or Stye (Hordeolum): This is the most common cause of outgrowths on the eyelids, often resulting from bacterial infections or blockage of the meibomian glands.
  • Other Likely diagnoses
    • Chalazion: A small bump on the eyelid due to a blocked oil gland, which can appear similar to a stye but is usually painless.
    • Molluscum contagiosum: A viral infection that causes small, pearly, or flesh-colored bumps on the skin, including the eyelids.
    • Papilloma: Benign growths that can occur on the eyelids, often caused by the human papillomavirus (HPV).
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Basal cell carcinoma: Although rare, this type of skin cancer can present as an outgrowth on the eyelid and requires early detection for effective treatment.
    • Squamous cell carcinoma: Another form of skin cancer that can appear on the eyelids, necessitating prompt medical attention.
    • Kaposi's sarcoma: A rare cancer that can cause lesions on the skin, including the eyelids, particularly in immunocompromised individuals.
  • Rare diagnoses
    • Xanthelasma: A condition characterized by small, yellowish patches or bumps on the eyelids due to lipid deposits, often associated with high cholesterol levels.
    • Sebaceous gland hyperplasia: Benign enlargements of the sebaceous glands that can appear as outgrowths on the eyelids.
    • Trichoepithelioma: A rare, benign tumor of the hair follicle that can occur on the eyelids.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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