From the Research
It is generally considered safe to take Tri-Lo-Marzia (ethinyl estradiol and levonorgestrel) birth control pills while using topical Minoxidil (Rogaine). There are no known significant drug interactions between these two medications when Minoxidil is used as directed as a topical solution for hair loss. Tri-Lo-Marzia works systemically by preventing ovulation through hormonal mechanisms, while topical Minoxidil works locally on the scalp to promote hair growth by increasing blood flow to hair follicles. Since topical Minoxidil has minimal systemic absorption when used correctly, it typically doesn't interfere with oral contraceptives 1.
However, if you're using oral Minoxidil (which is prescribed for blood pressure, not hair loss), you should consult your healthcare provider as this form has different considerations. As with any medication combination, it's always best to inform your healthcare provider about all medications you're taking, including over-the-counter products and supplements, to ensure there are no individual-specific concerns based on your complete medical history. A recent study on the safety of low-dose oral minoxidil for hair loss found that systemic adverse effects were infrequent and only 1.7% of patients discontinued treatment owing to adverse effects 2.
Another study on the efficacy and safety of combined topical estradiol with minoxidil vs. topical minoxidil in female pattern hair loss found that the use of a 0.01% 17α-ethinylestradiol with a 2% minoxidil solution in the treatment of FPHL does not seem to offer a statistically significant advantage compared with minoxidil alone and may carry a higher risk of associated menstrual irregularities 3.
It's also important to note that the safety of topical minoxidil solution has been evaluated in a one-year, prospective, observational study, which found that TMS is a safe and effective treatment for androgenetic alopecia, with no increases in cardiovascular events and no apparent increased risk for adverse pregnancy outcomes 1.
In terms of pharmacokinetic drug interactions with oral contraceptives, some studies have found that certain drugs may impair the efficacy of oral contraceptive steroids, leading to breakthrough bleeding and pregnancy, while others may interfere with the metabolism of other drugs 4. However, there is no firm evidence to suggest that minoxidil interacts with oral contraceptives in a way that would affect their efficacy or safety.
In summary, the combination of Tri-Lo-Marzia and topical Minoxidil is considered safe, but it's always best to consult with a healthcare provider to discuss individual-specific concerns and ensure safe use.