Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 16, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for ECG with Digoxin Effect and Irregular Rhythm

Single Most Likely Diagnosis

  • Atrial Fibrillation with Digoxin Effect: This is the most likely diagnosis given the irregular rhythm and the presence of digoxin effect on the ECG, which is often used to control ventricular rate in atrial fibrillation.

Other Likely Diagnoses

  • Atrial Flutter with Variable Block: The irregular rhythm could also suggest atrial flutter with variable block, especially if the patient is on digoxin, which can cause variable block.
  • Multifocal Atrial Tachycardia: Although less common, multifocal atrial tachycardia could present with an irregular rhythm and might be considered in the differential, especially if the patient has underlying lung disease.

Do Not Miss Diagnoses

  • Paroxysmal Supraventricular Tachycardia (PSVT) with Variable Block: Although PSVT typically presents with a regular rhythm, it's crucial not to miss this diagnosis, as it can be life-threatening if not promptly treated, and digoxin can sometimes cause variable block.
  • Wolff-Parkinson-White (WPW) Syndrome with Atrial Fibrillation: This condition can present with an irregular wide complex tachycardia and is a medical emergency due to the risk of rapid ventricular response and potential degeneration into ventricular fibrillation.

Rare Diagnoses

  • Chaotic Atrial Tachycardia: A rare condition characterized by an irregular atrial rhythm that can be difficult to distinguish from atrial fibrillation but typically has a more organized appearance on ECG.
  • Digitalis-Induced Arrhythmias: While digoxin effect is noted, other digitalis-induced arrhythmias such as bidirectional ventricular tachycardia are rare but should be considered in patients on digoxin, especially with toxic levels.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.