What is the next dose of Wegovy (semaglutide) after 0.5mg weekly?

From the Guidelines

The next dose of Wegovy (semaglutide) after 0.5mg weekly is 1.0mg weekly. After taking the 0.5mg dose for 4 weeks, patients should increase to the 1.0mg dose and continue this for another 4 weeks, as recommended in the approved indications and dosing for semaglutide 1. This gradual dose escalation is designed to minimize gastrointestinal side effects such as nausea, vomiting, and diarrhea, which are common with semaglutide. Following the 1.0mg dose, the standard progression continues to 1.7mg is not mentioned in the evidence but 2.4mg weekly for weight management among adult patients with BMI >30 kg/m2 or BMI >27 kg/m2 with at least one weight-related comorbidity, is the maintenance dose of semaglutide for weight management. Each dose increase should occur after completing the full 4 weeks at the previous dose level. It's essential to take Wegovy on the same day each week, with or without food, and to contact your healthcare provider if you experience severe or persistent side effects that might require dose adjustment or additional management. Recent studies have shown that semaglutide has benefits beyond weight loss, including reducing the risk of cardiovascular events such as heart attacks, strokes, and major adverse cardiovascular events 1.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION • Start at 0.25 mg once weekly. After 4 weeks, increase the dose to 0.5 mg once weekly. If after at least 4 weeks additional glycemic control is needed, increase to 1 mg once weekly (2.1). The next dose of Wegovy (semaglutide) after 0.5mg weekly is 1 mg once weekly if additional glycemic control is needed, after at least 4 weeks on the 0.5mg dose 2.

From the Research

Dosing Schedule of Wegovy (Semaglutide)

The dosing schedule of Wegovy (semaglutide) is as follows:

• The initial dose is 0.25 mg per week for 4 weeks 3
• The dose is then increased to 0.5 mg per week for 4 weeks 3
• The next dose after 0.5 mg per week is 1.0 mg per week for 4 weeks 3
• The final maintenance dose is 2.4 mg per week 4, 5, 3

Important Considerations

Some important considerations for the dosing schedule of Wegovy (semaglutide) include:

• The dose should be increased gradually to minimize gastrointestinal adverse events 6, 3
• The medication should be administered via subcutaneous injection once a week 4, 5, 3
• Patients should be monitored for potential adverse events, such as nausea, diarrhea, and vomiting 6, 3