From the Research
The recommended treatment for Streptococcus agalactiae urinary tract infection is typically a course of penicillin, ampicillin, or amoxicillin for 5-7 days for uncomplicated cases, with dosages of amoxicillin typically at 500 mg three times daily or ampicillin 500 mg four times daily, as supported by the most recent study 1. This recommendation is based on the fact that Streptococcus agalactiae is naturally sensitive to penicillins, which inhibit cell wall synthesis in the bacteria.
- The most recent study 1 found that all GBS strains were fully sensitive to penicillin, ampicillin, and vancomycin, making these antibiotics the best choice for treatment.
- For patients with penicillin allergies, alternatives include cephalosporins like cefazolin or ceftriaxone, as suggested by earlier studies 2, 3.
- It's essential to complete the full course of antibiotics even if symptoms improve before completion, and adequate hydration is also recommended during treatment.
- Follow-up urine cultures may be necessary to confirm clearance of the infection, especially in pregnant women or patients with recurrent infections, as noted in study 4.
- High resistance to clindamycin and tetracycline was observed in the most recent study 1, making these antibiotics less suitable for treatment.
- The study 5 from 1982 found that amoxicillin was 2.5 times as active as ampicillin, but this information is less relevant given the more recent findings.