What about antitussigen (antitussive) drugs for cough treatment?

From the Guidelines

Antitussive medications, such as opioids, are the most effective treatment for cough in patients with lung cancer, and should be used when other treatments have failed. The use of antitussive drugs, such as codeine, hydrocodone, and dextromethorphan, can be helpful in managing persistent, dry coughs in patients with lung cancer 1. These medications work by suppressing the cough reflex in the brain, and can provide relief from coughing. However, they should not be used for productive coughs, as coughing helps clear mucus and other material from the airways.

Some key points to consider when using antitussive medications for cough in patients with lung cancer include:

• Opioids, such as codeine and hydrocodone, are the most effective antitussive medications for cough in patients with lung cancer 1
• Dextromethorphan, a non-opioid antitussive, can also be effective in managing cough in patients with lung cancer 1
• Antitussive medications should be used selectively and for short durations, as they can have side effects such as drowsiness, constipation, and risk of dependence 1
• Non-drug approaches, such as staying hydrated, using honey, and using humidifiers, can also help manage coughs in patients with lung cancer 1

In terms of specific medications and dosages, the following may be considered:

• Codeine: 30-60 mg every 4-6 hours as needed 1
• Hydrocodone: 5 mg every 4-6 hours as needed 1
• Dextromethorphan: 10-30 mg every 4-8 hours as needed 1

It's worth noting that the evidence for the use of antitussive medications in patients with lung cancer is limited, and more research is needed to fully understand their effectiveness and safety in this population 1. However, based on the available evidence, antitussive medications, such as opioids, are a reasonable treatment option for cough in patients with lung cancer, and should be used when other treatments have failed.

From the FDA Drug Label

BENZONATATE is indicated for the symptomatic relief of cough. Uses temporarily relieves: cough due to minor throat and bronchial irritation as may occur with a cold or inhaled irritants Benzonatate, a non-narcotic oral antitussive agent

Antitussigen (antitussive) drugs are used for cough treatment.

• Benzonatate is a non-narcotic oral antitussive agent indicated for the symptomatic relief of cough 2.
• Codeine is used to temporarily relieve cough due to minor throat and bronchial irritation 3. These drugs can help relieve cough symptoms, but it's essential to use them as directed and under medical supervision. 2

From the Research

Antitussigen (Antitussive) Drugs for Cough Treatment

• Antitussive drugs are used to suppress cough and can be classified into two main categories: centrally acting and peripherally acting 4.
• Centrally acting antitussives include opioids (such as morphine, codeine, and hydrocodone) and non-opioids (such as dextromethorphan), while peripherally acting antitussives include drugs that act directly or indirectly on the cough receptors 4, 5.
• The choice of antitussive drug depends on various factors, including the patient's current medications, previous antitussive use, and the presence of other symptoms 4.
• Studies have shown that antitussive drugs such as benzonatate, codeine, hydrocodone, and dextromethorphan are effective in reducing cough in patients with acute and chronic cough 4, 6, 7.
• However, the use of antitussive drugs can be associated with side effects, such as drowsiness, nausea, and constipation, and may lead to physical dependence 5, 8.
• Newer antitussive drugs, such as nociceptin and antagonists of TRPV1, are being developed and may offer improved efficacy and safety profiles 5, 8.

Types of Antitussigen Drugs

• Centrally acting opioids:
  • Morphine
  • Codeine
  • Hydrocodone
• Centrally acting non-opioids:
  • Dextromethorphan
• Peripherally acting antitussives:
  • Moguisteine
  • Levodropropizine
• Other antitussive drugs:
  • Benzonatate
  • Clobutinol
  • Dihydrocodeine

Efficacy and Safety of Antitussigen Drugs

• Antitussive drugs have been shown to be effective in reducing cough in patients with acute and chronic cough 4, 6, 7.
• However, the efficacy of antitussive drugs can vary depending on the underlying cause of the cough and the individual patient's response to treatment 5, 8.
• Antitussive drugs can be associated with side effects, such as drowsiness, nausea, and constipation, and may lead to physical dependence 5, 8.
• The safety and efficacy of antitussive drugs must be carefully evaluated in clinical trials to ensure their safe and effective use in patients with cough 4, 5, 8.