Can Liletta (levonorgestrel-releasing intrauterine system) be left in place for up to eight years if it was inserted in 2020?

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Last updated: February 25, 2025View editorial policy

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From the Research

Yes, a Liletta IUD inserted in 2020 can be left in place for up to eight years, as the most recent and highest quality study 1 demonstrates its efficacy and safety through 8 years of use. The study published in the American Journal of Obstetrics and Gynecology in 2022, evaluated the efficacy and safety of the levonorgestrel 52 mg intrauterine system during years 7 and 8 of use, and found that the device is highly effective over 8 years of use and has an excellent extended safety profile. Some key points to consider include:

  • The cumulative life-table pregnancy rate in the primary efficacy population through year 8 was 1.32 (95% confidence interval, 0.69-2.51) 1
  • The study found that the levonorgestrel 52 mg intrauterine system is highly effective over 8 years of use, with a Pearl Index of 0.49 (95% confidence interval, 0.06-1.78) in year 7 and no pregnancies occurred in year 8 1
  • The device has an excellent extended safety profile, with low rates of expulsion, perforation, and pelvic infection 1 It's essential to consult with your healthcare provider to determine the best course of action for your specific situation, as they can review your medical records and provide personalized guidance. However, based on the most recent and highest quality evidence, leaving a Liletta IUD inserted in 2020 in place for up to eight years is a safe and effective option.

References

Research

Levonorgestrel 52 mg intrauterine system efficacy and safety through 8 years of use.

American journal of obstetrics and gynecology, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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