From the Research
The maximum recommended dose of Dayvigo (lemborexant) for insomnia is 10 mg taken orally once daily, immediately before bedtime. The typical starting dose is 5 mg, which is effective for many patients, but can be increased to the maximum 10 mg dose if needed for better efficacy, as shown in a study published in 2024 1. Dayvigo should be taken only when the patient has at least 7 hours remaining before planned awakening to avoid morning drowsiness and impairment. Food can delay the effect of Dayvigo, so it should be taken on an empty stomach for faster sleep onset. This medication works by blocking orexin receptors in the brain, which helps regulate the sleep-wake cycle. Patients should be aware that Dayvigo may cause side effects including sleepiness during the day, headache, and abnormal dreams. The medication should be used at the lowest effective dose for the shortest duration necessary, as it is a controlled substance (Schedule IV) with potential for dependence. Some key points to consider when prescribing Dayvigo include:
- Patients with severe liver impairment should not exceed 5 mg daily, as shown in a study published in 2021 2.
- Dayvigo has been shown to be effective in older adults, with improvements in sleep variables and no next-morning residual effects, as demonstrated in a study published in 2024 3.
- The efficacy and safety of Dayvigo have been evaluated in several clinical trials, including a comprehensive review published in 2024 4, which highlights its potential as a treatment option for insomnia. It is essential to weigh the benefits and risks of Dayvigo and consider individual patient factors when determining the optimal dose and treatment duration, as supported by the findings of a study published in 2021 5.