From the Research
NAD supplementation may potentially interact with several medications you've listed, though research on these specific interactions is limited, and it is crucial to consult with a healthcare provider before combining NAD with any of these medications. The potential interactions can be complex and involve various mechanisms, including pharmacodynamic and pharmacokinetic interactions, as discussed in studies such as 1.
Potential Interactions with Listed Medications
- Wegovy (semaglutide): There's a theoretical concern that NAD might interact with Wegovy since both can affect metabolic pathways, though no direct interactions are documented.
- Skyrizi (risankizumab): NAD's role in immune function suggests caution when combining it with immunomodulatory drugs like Skyrizi.
- Naltrexone: NAD might influence the effectiveness of naltrexone, which affects opioid receptors and addiction pathways.
- Estrace (estradiol) and DHEA: Hormonal medications like Estrace and DHEA could have complex interactions with NAD since they all influence metabolic and cellular processes.
- Captopril and spironolactone: Blood pressure medications might be affected as NAD impacts cardiovascular function.
- Prednisone: Prednisone's anti-inflammatory effects could theoretically be modified by NAD's role in inflammation.
- Adderall XR, tizanidine, tramadol, and clonazepam: Neurological medications warrant particular caution as NAD affects neurotransmitter systems.
Considerations for Clinical Practice
As highlighted in studies such as 2 and 3, drug interactions can significantly impact patient outcomes, including morbidity, mortality, and quality of life. It is essential to consider these potential interactions in the context of individual patient factors, including dosage, specific health conditions, and medication combinations. The most recent study 1 emphasizes the importance of patient counseling and collaboration between healthcare teams to avoid adverse effects and optimize medication therapy.
Recommendation
Given the potential for interactions and the limited research on specific interactions between NAD and the listed medications, it is recommended to consult with a healthcare provider before initiating NAD supplementation, especially considering the principles outlined in 4 regarding drug-nutrient interactions. This approach ensures that any potential risks are mitigated, and the benefits of NAD supplementation can be realized while minimizing adverse effects.