From the Research
Marijuana can potentially trigger seizures in individuals with epilepsy or seizure disorders, though its effects vary significantly between individuals. For people with epilepsy, it's generally recommended to approach marijuana use with caution and consult with a neurologist before using any cannabis products. Some research suggests that THC (tetrahydrocannabinol), the main psychoactive component in marijuana, may lower seizure thresholds in susceptible individuals, potentially increasing seizure risk 1. Conversely, CBD (cannabidiol), another component of marijuana, has demonstrated anticonvulsant properties and is even available as an FDA-approved medication (Epidiolex) for certain severe forms of epilepsy at doses ranging from 5-20 mg/kg/day.
The interaction between marijuana and seizure medications can also be problematic, as THC and CBD may affect liver enzymes that metabolize many antiepileptic drugs, potentially altering their blood levels. Factors such as the specific cannabis strain, ratio of THC to CBD, consumption method, dosage, and individual sensitivity all influence potential seizure risk. If you have epilepsy and are considering using marijuana, tracking any changes in seizure frequency or severity following use is important, and immediately discontinue use if seizures worsen. A recent case study highlighted the potential for chronic synthetic marijuana use to lead to first-onset seizures as a withdrawal symptom 1, emphasizing the need for caution and medical supervision.
Key considerations for individuals with epilepsy or seizure disorders include:
- Consulting with a neurologist before using marijuana or any cannabis products
- Being aware of the potential for THC to lower seizure thresholds and CBD to have anticonvulsant effects
- Monitoring changes in seizure frequency or severity after marijuana use
- Understanding the potential interactions between marijuana and seizure medications
- Recognizing the risks associated with chronic synthetic marijuana use, including the possibility of seizures as a withdrawal symptom 1.