From the Guidelines
Several natural supplements may partially mimic GLP-1 effects, though none match the potency of pharmaceutical GLP-1 receptor agonists, with berberine showing the most promise by improving insulin sensitivity and potentially stimulating GLP-1 secretion 1. When considering natural supplements that can mimic the effects of Glucagon-like peptide-1 (GLP-1), it's essential to prioritize those with the most substantial evidence supporting their efficacy and safety.
- Berberine (500-1500mg daily in divided doses) is a promising option, as it improves insulin sensitivity and may stimulate GLP-1 secretion.
- Other potential supplements include apple cider vinegar (1-2 tablespoons diluted before meals), cinnamon (1-6g daily), and fenugreek (5-10g daily), which work through various mechanisms such as slowing gastric emptying and improving insulin sensitivity.
- Dietary approaches like consuming prebiotic fibers (25-30g daily from foods like chicory root, Jerusalem artichokes, and legumes), fermented foods containing probiotics, and following a Mediterranean diet pattern rich in olive oil, nuts, and vegetables may also naturally boost GLP-1 levels. It's crucial to note that these natural approaches have milder effects than prescription GLP-1 medications and work through different mechanisms, often indirectly affecting GLP-1 pathways rather than directly activating GLP-1 receptors 1. Always consult with a healthcare provider before starting supplements, especially if you have diabetes or are taking medications, to ensure safe and effective management of your condition.
From the Research
Natural Supplements that Mimic GLP-1 Effects
There are several natural supplements that have been studied for their potential to mimic the effects of Glucagon-like peptide-1 (GLP-1). Some of these supplements include:
- Berberine: a herbal-based constituent that has been shown to exert an influence on GLP-1 release 2
- Tea: certain types of tea may have modulatory effects on GLP-1 expression and secretion 2
- Curcumin: a compound found in turmeric that may have an influence on GLP-1 release 2
- Cinnamon: a spice that has been shown to have an effect on GLP-1 secretion 2
- Wheat: certain components of wheat may have an influence on GLP-1 release 2
- Soybean: isoflavones found in soybeans may have modulatory effects on GLP-1 expression and secretion 2
- Resveratrol: a compound found in grapes and other plants that may have an influence on GLP-1 release 2
- Gardenia: a herbal-based constituent that has been shown to exert an influence on GLP-1 release 2
Mechanism of Action
These natural supplements may mimic the effects of GLP-1 by:
- Increasing insulin secretion 3, 4, 5
- Decreasing glucagon release 3, 4, 5
- Slowing gastric emptying 3, 4, 5
- Reducing food intake 6
- Stimulating (pro)insulin biosynthesis 6
Clinical Use
While these natural supplements may have potential benefits, it is essential to note that they may not be as effective as synthetic GLP-1 receptor agonists, which have been shown to significantly improve glycemic parameters and reduce body weight 3, 4, 5. Additionally, the use of these supplements should be approached with caution, and individuals with type 2 diabetes should consult with their healthcare provider before adding any new supplements to their treatment plan.