From the Research
The most effective gonadotropin-releasing hormone (GnRH) agonist for suppressing puberty in transgender adolescents is triptorelin, as it has been shown to effectively suppress puberty with minimal side effects, according to the most recent and highest quality study available 1. When considering the use of GnRH agonists for puberty suppression in transgender adolescents, it is essential to prioritize the individual's specific needs and medical history. The decision to use GnRH agonists should be made collaboratively between the teen, their parents/guardians, and a medical team including pediatric endocrinologists and mental health professionals specializing in gender care. Some key points to consider when using GnRH agonists for puberty suppression include:
- The medication should be prescribed by a specialist after thorough evaluation, taking into account the individual's medical history and needs.
- Regular monitoring through blood tests and check-ups is essential to assess effectiveness and manage potential side effects.
- The use of GnRH agonists can have benefits, such as reducing the impact of dysphoria due to ongoing physical development, but also potential drawbacks, such as the impact on fertility and surgical options.
- The timing of GnRH agonist treatment is crucial, as delaying treatment for as long as possible can increase the chances of successful fertility preservation.
- Urologists and gynaecologists should be involved early in and throughout the treatment pathway to maximize future functional and surgical outcomes. It is also important to consider the individual's perceptions and concerns regarding puberty suppression, as well as the potential long-term effects of GnRH agonist treatment, as highlighted in studies such as 2. Overall, while triptorelin has been shown to be an effective and safe option for puberty suppression in transgender adolescents, the decision to use GnRH agonists should be made on a case-by-case basis, taking into account the individual's unique needs and circumstances, and with careful consideration of the potential benefits and drawbacks, as discussed in studies such as 3 and 4.