From the Research
High-quality NAD+ transdermal patches, such as Alive by Science's NAD+ Transdermal Patches, Renue by Science NAD+ Patches, and Nadovim's NAD+ Dermal Patches, are available for delivering NAD+ through the skin over 12-24 hours. When selecting a patch, look for those with pharmaceutical-grade NAD+ and evidence of good bioavailability, as noted in studies on transdermal delivery systems 1, 2. Most patches are designed to be applied to clean, hairless skin areas with good blood flow, such as the inner wrist, upper arm, or abdomen, and are typically worn for 12-24 hours before replacement.
Transdermal delivery may offer advantages over oral supplements because NAD+ is easily degraded in the digestive system, as discussed in the context of micronutrient supplementation 3. The patches work by slowly releasing NAD+ through the skin into the bloodstream, potentially supporting cellular energy production, DNA repair, and other metabolic processes. However, scientific evidence specifically for transdermal NAD+ delivery remains limited compared to other administration routes, and results may vary between individuals.
Key considerations for the use of transdermal patches include:
- Proper application and removal techniques
- Selection of suitable skin sites for application
- Avoidance of external heat sources during use
- Potential interactions with other medications or health conditions
- Monitoring for adverse effects, such as skin irritation or allergic reactions, as noted in studies on transdermal patch safety and efficacy 4, 5.
Given the current state of evidence, it is essential to prioritize patches with demonstrated bioavailability and safety profiles, and to consult with a healthcare professional before starting any new supplement regimen, including transdermal NAD+ patches.