What is the sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of transillumination for diagnosing pneumothorax in neonates?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 18, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Transillumination for diagnosing pneumothorax in neonates has a sensitivity of 0.87, a positive predictive value (PPV) of 0.96, and a negative predictive value (NPV) that can be calculated based on the provided sensitivity and specificity, as seen in the study by 1. The technique of transillumination involves placing a high-intensity fiber-optic light against the neonate's chest wall in a darkened room; a pneumothorax appears as increased illumination on the affected side compared to the normal side. This method is most useful as a rapid screening tool in emergency situations when a pneumothorax is suspected and radiographic confirmation would delay treatment. Some key points to consider when using transillumination include:

  • The test performs better in smaller, premature infants with thinner chest walls, and its accuracy decreases in larger or term infants.
  • Despite its utility as a quick bedside assessment, transillumination should not replace chest radiography for definitive diagnosis, as false positives can occur with conditions like severe pulmonary interstitial emphysema or subcutaneous emphysema, and false negatives may occur with smaller pneumothoraces or in larger infants.
  • When using this technique, proper darkening of the room and appropriate light source positioning are essential for optimal results, as noted in various studies including 2 and 3. It's also worth noting that other diagnostic methods, such as lung ultrasound, have been shown to be highly accurate in diagnosing pneumothorax in neonates, with a sensitivity of 1, as seen in the study by 1, and may be considered as an alternative or complementary diagnostic tool.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.