There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the Research
Renal Failure and NLRP3 Inflammasome Activation
- Renal failure in cats with Lyme disease can potentially activate the NLRP3 inflammasome, as evidenced by studies on the role of NLRP3 in kidney disease and autoimmunity 1.
- The NLRP3 inflammasome is an intracellular platform that converts pro-inflammatory cytokines to their active forms in response to 'danger' signals, which can be either host or pathogen derived 1.
- Activation of the NLRP3 inflammasome can lead to the release of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, and induce pyroptosis (lytic cell death) 2.
Lyme Disease and Renal Failure
- Lyme disease, caused by Borrelia burgdorferi, can lead to post-infectious glomerulonephritis (GN) and acute renal failure in humans 3.
- A case study reported a patient with acute renal failure in Lyme disease-associated focal proliferative mesangial nephropathy, highlighting the potential for Lyme disease to cause renal damage 3.
NLRP3 Inflammasome and Body Temperature
- There is no direct evidence in the provided studies to suggest that the NLRP3 inflammasome affects body temperature in cats with Lyme disease.
- However, studies have shown that the NLRP3 inflammasome plays a crucial role in innate immunity and can be activated by various stimuli, including pathogens and cellular stress 4, 5.
Pharmacological Inhibition of NLRP3 Inflammasome
- Several pharmacological inhibitors of the NLRP3 inflammasome have been identified, including MCC950 and 66PR, which have shown promise in treating inflammasome-mediated conditions 2, 5.
- These inhibitors can prevent the activation of the NLRP3 inflammasome and subsequent release of proinflammatory cytokines, potentially alleviating kidney function damage in diseases such as acute hemolytic transfusion reactions 5.