From the FDA Drug Label
Clobazam is a benzodiazepine indicated for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older ( 1) The indication for Clobazam is for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older 1.
- Key points:
- Age: 2 years or older
- Condition: Lennox-Gastaut syndrome (LGS)
- Treatment type: Adjunctive treatment of seizures
From the Research
Clobazam is primarily indicated for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients aged 2 years and older, as well as for refractory epilepsy, catamenial epilepsy, and as an adjunctive therapy for partial seizures. The typical starting dose for adults is 5-10 mg daily, gradually increasing to 20-40 mg daily in divided doses, while children usually start at 5 mg daily with gradual titration based on response 2. Clobazam works as a benzodiazepine that enhances the effect of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain, thereby reducing excessive neuronal activity that can lead to seizures. It has a longer half-life than many other benzodiazepines and may cause less sedation, making it suitable for long-term seizure management.
Some key points to consider when using Clobazam include:
- It is a 1,5-benzodiazepine with a wide spectrum of antiepileptic activity and is associated with less neurotoxicity than the 1,4-benzodiazepines 3
- It has been shown to be effective in the treatment of children with a wide range of epilepsies and seizure types 3
- It is well tolerated, safe, and very effective as an antiepileptic drug, with minimal side effects and is relatively inexpensive 4
- Patients should be monitored for side effects including drowsiness, dizziness, and potential for dependence or withdrawal symptoms if discontinued abruptly 2, 5
- Clobazam should be tapered gradually when discontinuing treatment to minimize withdrawal effects 2, 5
Overall, Clobazam is a useful addition to the treatment of epilepsy, particularly for patients with refractory or hard-to-treat seizure disorders. Its efficacy and safety profile make it a valuable option for clinicians to consider when managing patients with epilepsy 2, 5, 4.