From the FDA Drug Label
In the first study, the bupropion dose range was 300 mg to 600 mg per day administered in 3 divided doses; 78% of patients were treated with doses of 300 mg to 450 mg per day. The second study included 2 fixed doses of bupropion (300 mg and 450 mg per day) and placebo. The initial bupropion dose was 150 mg once daily for 1 week, followed by up-titration to 300 mg once daily.
The recommended dose of Wellbutrin (bupropion) for adults is:
- 300 mg to 450 mg per day for the treatment of major depressive disorder (MDD)
- 300 mg once daily for the prevention of seasonal major depressive episodes associated with seasonal affective disorder (SAD) 1
From the Research
The recommended dose of Wellbutrin (bupropion) for adults is typically started at 150 mg once daily in the morning for the immediate-release formulation, which may be increased to 150 mg twice daily after 3-4 days if well tolerated, as stated in the most recent and highest quality study available 2.
Key Considerations
- The maximum recommended dose is generally 450 mg per day for immediate-release (divided into three doses), 400 mg per day for SR (200 mg twice daily), and 450 mg once daily for XL, with doses taken at least 8 hours apart to reduce the risk of seizures.
- Bupropion works by inhibiting the reuptake of dopamine and norepinephrine in the brain, which helps regulate mood.
- Patients with hepatic or renal impairment, elderly patients, or those taking certain medications may require lower doses.
- Common side effects include dry mouth, insomnia, headache, and nausea, which often improve over time.
Formulation-Specific Guidance
- For the sustained-release (SR) formulation, treatment usually begins with 150 mg once daily in the morning, potentially increasing to 150 mg twice daily after 3 days.
- The extended-release (XL) formulation is typically started at 150 mg once daily in the morning, with a possible increase to 300 mg once daily after 3-4 days.
Clinical Evidence
- The efficacy and safety of bupropion have been established in various studies, including those comparing it to other antidepressants like SSRIs and SNRIs 3, 4.
- Bupropion has been shown to be effective in treating major depressive disorder, with a favorable tolerability profile and fewer sexual side effects compared to some other antidepressants 3, 4.