From the Guidelines
The recommended dosage of diosmin for treating hemorrhoids is typically 500 mg taken twice daily for acute hemorrhoid episodes, usually for 4-7 days, followed by a maintenance dose of 500 mg once daily for several weeks. For severe cases, some healthcare providers may recommend starting with 1000 mg (two 500 mg tablets) twice daily for the first few days. Diosmin is often formulated with hesperidin in products like Daflon or Venarus, which are flavonoid supplements that help strengthen vein walls and reduce inflammation. According to the most recent guidelines, in patients with complicated hemorrhoids, non-operative management is recommended as first-line therapy, with dietary and lifestyle changes, and flavonoids such as diosmin may be suggested to relieve symptoms 1. The exact dosage may vary depending on the individual case and the healthcare provider's recommendation. It's essential to consult with a healthcare provider before starting any treatment, especially if you have underlying health conditions or take other medications. Diosmin works by improving venous tone, reducing inflammation, and decreasing capillary permeability, which helps reduce swelling and discomfort associated with hemorrhoids 1. While generally well-tolerated, mild gastrointestinal side effects can occur. For optimal results, take diosmin with meals to improve absorption. Most patients experience symptom relief within a week, though complete resolution may take longer. It's crucial to follow the healthcare provider's guidance and monitor the symptoms to adjust the treatment plan as needed. In addition to diosmin, other non-operative treatments such as infrared photocoagulation, sclerotherapy, and rubber band ligation may be considered for patients with first-, second-, or third-degree hemorrhoids 1. However, the choice of treatment should be based on the individual case and the healthcare provider's professional judgment.
From the Research
Dosage of Diosmin for Hemorrhoids
The recommended dosage of diosmin for treating hemorrhoids varies depending on the study and the specific formulation used.
- A study published in 2003 2 found that a micronised purified flavonoid fraction (MPFF) containing 90% diosmin and 10% flavonoids, given at a dose of 500 mg twice daily, significantly improved symptoms of chronic venous insufficiency and haemorrhoids.
- Another study from 2000 3 used purified diosmin at a dose of 2 x 450 mg tablets twice daily for the first 7 days, then 1 tablet twice daily for up to 2 months, and found it to be effective in decreasing pain and bleeding in patients with hemorrhoids.
- A 1988 study 4 used topical diosmin (venosmine) to treat acute hemorrhoid pathology, but did not provide information on oral dosage.
- A 1995 study 5 used Daflon 500 mg (containing diosmin 450 mg and hesperidin 50 mg) for 1 week after haemorrhoidectomy to reduce bleeding, and found it to be effective.
- A 2018 review 6 noted that there is no conclusive evidence to prefer a specific daily dosage of diosmin for treatment of acute hemorrhoids, and that dosages of 1800 mg per day of purified diosmin may be as effective as 3000 mg per day of micronized fraction of flavonoids.
Key Findings
- The most commonly used dosage of diosmin for hemorrhoids is 500-900 mg twice daily, although the optimal dosage is not well established.
- Diosmin may be used in combination with other treatments, such as sclerotherapy, surgery, and compression therapy, to treat hemorrhoids.
- The efficacy and safety of diosmin for hemorrhoids have been demonstrated in several studies, although more research is needed to fully establish its benefits and optimal dosage.