From the FDA Drug Label
DOSAGE AND ADMINISTRATION Benztropine mesylate tablets should be used when patients are able to take oral medication. The usual daily dose is 1 to 2 mg, with a range of 0. 5 to 6 mg orally or parentally. In idiopathic parkinsonism, therapy may be initiated with a single daily dose of 0. 5 to 1 mg at bedtime. In some patients, this will be adequate; in others 4 to 6 mg a day may be required.
The proper usage and dosage of Congentin (Benztropine) 1 mg for treating Parkinson's disease is to initiate therapy with a single daily dose of 0.5 to 1 mg at bedtime, which may be adequate for some patients, while others may require 4 to 6 mg a day. The dosage must be individualized according to age, weight, and the type of parkinsonism being treated. 1
From the Research
Benztropine (Cogentin) should be prescribed for Parkinson's disease at an initial dose of 0.5 to 1 mg daily, gradually increasing to 2-6 mg daily divided into 1-2 doses as needed, with caution in elderly patients and those with certain conditions like glaucoma, prostatic hypertrophy, or cardiovascular disease 2. The medication works by blocking acetylcholine receptors in the brain, helping to restore balance between dopamine and acetylcholine neurotransmitters, which reduces tremors and rigidity.
- Treatment usually begins with a lower dose, especially in elderly patients, to minimize side effects.
- Benztropine should be taken exactly as prescribed, preferably at the same time each day to maintain consistent blood levels.
- It's essential to note that this medication treats symptoms but doesn't slow disease progression.
- Common side effects include dry mouth, blurred vision, constipation, and urinary retention.
- Patients should not stop taking benztropine suddenly as this may worsen Parkinson's symptoms.
- Regular follow-up with a healthcare provider is necessary to monitor effectiveness and adjust dosage as needed, considering the lack of pharmacokinetic information for this class of drugs in the elderly 3.
- The use of benztropine in combination with other medications, such as levodopa, may be beneficial in some cases, as shown in a study where the combination of Sinemet and Cogentin resulted in significantly greater improvement than Sinemet plus placebo 4.