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From the Research
Indications for Nattokinase
The indications for Nattokinase (subtilisin NAT) are based on its potential health benefits, which include:
- Cardiovascular health: Nattokinase has been shown to have fibrinolytic, antithrombotic, and antihypertensive effects, making it a potential dietary supplement for the benefit of cardiovascular health 1, 2, 3
- Reduction of blood clotting factors: Nattokinase has been found to decrease plasma levels of fibrinogen, factor VII, and factor VIII, which are associated with an increased risk of cardiovascular disease (CVD) 2
- Improvement of blood viscosity and red blood cell aggregation: Nattokinase has been shown to decrease red blood cell aggregation and whole blood viscosity, which can help improve blood flow and reduce the risk of cardiovascular disease 4
- Antihypertensive effects: Nattokinase has been found to reduce blood pressure in hypertensive individuals, with more robust effects seen in males 3
- Reduction of von Willebrand factor: Nattokinase has been found to decrease von Willebrand factor, a cardiovascular risk marker, in females 3
Potential Therapeutic Applications
Nattokinase may have potential therapeutic applications in the treatment of:
- Cardiovascular diseases, such as hypertension, thrombosis, and atherosclerosis 1, 2, 3
- Conditions associated with blood clotting and fibrinolysis, such as deep vein thrombosis and pulmonary embolism 2, 4
- Diseases associated with inflammation and oxidative stress, such as cancer and neurodegenerative disorders 5