How do I use Anusol (hydrocortisone acetate) suppositories for hemorrhoid treatment?

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Last updated: June 19, 2025View editorial policy

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From the Guidelines

To effectively use Anusol (hydrocortisone acetate) suppositories for hemorrhoid treatment, follow the instructions carefully and be aware of the potential risks and benefits, as the cornerstone of medical therapy for hemorrhoids, especially first-degree ones, involves adequate intake of fiber and water, with topical corticosteroids like Anusol being useful for managing perianal skin irritation 1. When using Anusol suppositories, it's essential to start by washing your hands thoroughly, then remove the suppository from its wrapper. Lie on your side with knees bent toward your chest, or stand with one leg raised on a chair. Gently insert the pointed end of the suppository into your rectum using your finger, pushing it about one inch inside, then wash your hands again. For best results, use after a bowel movement and try to retain the suppository for 15-20 minutes. Some key points to consider when using Anusol suppositories include:

  • Typically, you should use one suppository 2-3 times daily for up to 7 days, unless directed otherwise by your doctor.
  • The hydrocortisone in Anusol works by reducing inflammation, itching, and swelling associated with hemorrhoids.
  • If symptoms persist beyond a week, consult your healthcare provider.
  • Avoid using more than prescribed as prolonged use can lead to thinning of rectal tissue, a concern also highlighted by the american gastroenterological association technical review on the diagnosis and treatment of hemorrhoids 1.
  • Store suppositories in a cool place, as they may melt at higher temperatures, making insertion difficult. It's also important to note that while Anusol can provide relief for hemorrhoid symptoms, the almost-universal recommendations for managing hemorrhoids include adding dietary fiber and avoiding straining at stool, with some studies showing that the use of psyllium can reduce hemorrhoidal bleeding and painful defecation 1.

From the FDA Drug Label

Warnings For external use only ... do not put directly into the rectum by using fingers or any mechanical device or applicator The FDA drug label does not answer the question.

From the Research

Using Anusol Suppositories for Hemorrhoid Treatment

To use Anusol (hydrocortisone acetate) suppositories for hemorrhoid treatment, follow these steps:

  • Insert one suppository into the rectum twice daily, in the morning and at bedtime, for the recommended duration, typically 7 days 2.
  • Ensure to wash your hands before and after inserting the suppository.
  • It is essential to follow the instructions provided by your healthcare provider or the product's packaging for the correct usage.

Potential Benefits and Side Effects

The use of Anusol suppositories may provide relief from hemorrhoid symptoms, including bleeding, prolapse size, and anal pain 2.

  • However, patients may experience adverse events, such as anal pain and bleeding, as reported in a study comparing a commercialized rectal suppository containing hydrocortisone and cinchocaine with a rectal suppository containing Cissus quadrangularis Linn. and Acmella paniculata extracts 2.

Alternative Treatments

Other treatments for hemorrhoids are available, including:

  • Rubber band ligation, a simple and effective method for treating symptomatic second- and third-degree hemorrhoids 3, 4.
  • Topical products containing sucralfate, which act as a mechanical barrier to facilitate healing 5.
  • The Rectal Rocket, a uniquely designed suppository that delivers lidocaine and hydrocortisone directly to the site of inflammation 6.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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