How long do muscle twitches caused by caffeine overdose last?

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Last updated: June 19, 2025View editorial policy

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From the Research

Muscle twitches caused by caffeine overdose typically last from a few hours to 24 hours, depending on how much caffeine was consumed and individual factors like metabolism and tolerance. These twitches occur because caffeine blocks adenosine receptors and increases neurotransmitter activity, leading to overstimulation of the nervous system and muscles. The half-life of caffeine in the body is about 5-6 hours for most adults, meaning it takes this long for the body to eliminate half the caffeine consumed. To reduce symptoms, stop caffeine intake immediately, drink plenty of water to help flush the caffeine from your system, and rest. In severe cases with persistent twitching beyond 24 hours or if accompanied by serious symptoms like chest pain, racing heartbeat, or difficulty breathing, medical attention should be sought. Most people will find that symptoms gradually diminish as the caffeine is metabolized and eliminated from the body, as supported by studies such as 1 which examined twitch potentiation and caffeine contractures in isolated rat soleus muscle, and 2 which investigated the actions of caffeine on fast- and slow-twitch muscles of the rat. Key factors influencing the duration of muscle twitches include:

  • Amount of caffeine consumed
  • Individual metabolism and tolerance
  • Presence of other symptoms It is essential to prioritize caution and seek medical attention if symptoms persist or worsen over time, as indicated by studies such as 3 which highlighted the importance of careful consideration in the management of muscle relaxants. Overall, the management of muscle twitches caused by caffeine overdose should focus on supportive care, monitoring, and addressing any underlying concerns, as informed by the latest research and evidence-based practices.

References

Research

Twitch potentiation and caffeine contractures in isolated rat soleus muscle.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1983

Research

Muscle relaxants for pain management in rheumatoid arthritis.

The Cochrane database of systematic reviews, 2012

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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