From the Research
Muscle twitching typically begins within 1-2 hours after caffeine ingestion, as seen in a case report where a 20-year-old woman presented with severe agitation, tremor, and vomiting approximately 1-2 hours after suicidal ingestion of concentrated caffeine 1. The onset of muscle twitching depends on several factors, including the dose consumed, individual sensitivity, and whether caffeine was consumed on an empty stomach or with food.
- Higher doses of caffeine, typically above 200-400mg, can cause more pronounced effects, including increased muscle sensitivity and spontaneous contractions, experienced as twitching.
- Caffeine stimulates the central nervous system by blocking adenosine receptors, which increases neuronal firing and releases excitatory neurotransmitters like dopamine and norepinephrine, leading to heightened neural activity.
- People with caffeine sensitivity, anxiety disorders, or those taking certain medications may experience more pronounced twitching at lower doses. To minimize these effects, consider reducing caffeine intake, avoiding consumption late in the day, staying hydrated, and ensuring adequate magnesium intake, as deficiency can exacerbate muscle twitching. It is essential to note that the relationship between caffeine and muscle twitching can be influenced by various factors, including individual tolerance and sensitivity, as well as the presence of underlying medical conditions, such as epilepsy, where caffeine may increase seizure susceptibility 2, 3.