From the Guidelines
I strongly advise against combining 2mg of nicotine spray with 700mg of caffeine and 1.5 teaspoons of salt, as this mixture could be extremely dangerous and potentially life-threatening. This combination would create a dangerous synergistic effect of stimulants (nicotine and caffeine) while adding a high sodium load. The 700mg of caffeine alone far exceeds the recommended safe daily limit of 400mg and could cause severe cardiovascular effects including dangerous heart rhythm disturbances, extreme hypertension, seizures, and even heart attack, as supported by the study 1. Adding nicotine, another stimulant, would further amplify these risks. The 1.5 teaspoons of salt (approximately 8,700mg of sodium) is nearly four times the recommended daily sodium intake and could cause severe electrolyte imbalances, extreme thirst, and contribute to hypertensive crisis when combined with stimulants. This combination could overwhelm your cardiovascular system, potentially leading to organ damage or failure. If someone has consumed this combination, they should seek immediate emergency medical attention. It's worth noting that nicotine replacement therapy (NRT) can be effective for smoking cessation, as shown in studies 1 and 1, but it should be used under medical guidance and in appropriate doses. However, in the context of this question, the primary concern is the safety of combining nicotine with high doses of caffeine and salt, which poses significant risks to morbidity, mortality, and quality of life.
From the Research
Effects of Adding 2mg of Nicotine Spray
- The combination of nicotine and caffeine can have additive effects on energy expenditure and substrate utilization 2.
- A study found that 1mg of nicotine has a pronounced thermogenic effect, which can be increased by approximately 100% by adding 100mg of caffeine 2.
- However, increasing the nicotine dose to 2mg does not increase the thermogenic effect but produces side effects in most subjects 2.
- The appetite-suppressant effect of nicotine is enhanced by caffeine, with combinations of 1mg of nicotine with caffeine seeming to be well tolerated 3.
Interaction with Caffeine and Salt
- The effects of nicotine and caffeine on subjective arousal and cardiovascular responses are generally additive or greater than additive 4.
- A combination of 700mg of caffeine and 2mg of nicotine spray may have synergistic effects on energy expenditure and substrate utilization, but the exact effects are unclear.
- The addition of 1.5 teaspoons of salt to this combination may not have a significant impact on the effects of nicotine and caffeine, as there is limited research on the interaction between salt and these substances.
Potential Risks and Side Effects
- Nicotine can cause minor irritation of the site through which it is administered, and in rare cases can cause non-ischaemic chest pain and palpitations 5.
- High doses of nicotine (2mg) can produce side effects such as nausea 3.
- The combination of nicotine, alcohol, and caffeine may increase the risk of gastric mucosal damage induced by certain drugs 6.