From the Research
Berberine patches should be used with caution in patients with a history of microscopic hematuria, as there is currently insufficient evidence to determine their effects on renal function in this population. The potential effects of berberine patches on renal function in patients with microscopic hematuria are not well understood, and the available evidence is primarily based on oral berberine administration. While some studies suggest that oral berberine may have protective effects on kidney function, such as reducing oxidative stress and inflammation 1, 2, others indicate that patients with pre-existing renal concerns, including microscopic hematuria, may be at increased risk of adverse renal outcomes 3, 4, 5. Given the lack of direct evidence on the use of berberine patches in patients with microscopic hematuria, it is recommended that patients with a history of microscopic hematuria consult with a nephrologist before using berberine patches, to discuss the potential risks and benefits and to monitor their kidney function if they decide to use these patches. This cautious approach is warranted due to the potential for berberine to influence various metabolic pathways that may impact renal function, and the need for further research to establish its safety profile in patients with kidney concerns. Some studies have investigated the relationship between hematuria and renal outcomes in immunoglobulin A nephropathy, suggesting that microscopic hematuria may be associated with an increased risk of end-stage renal disease (ESRD) 5. However, the evidence is not directly applicable to the use of berberine patches, and further research is needed to fully understand their effects on renal function in patients with microscopic hematuria. In the meantime, patients with a history of microscopic hematuria should approach berberine patches with caution and seek personalized guidance from a nephrologist.