From the Research
Lotrisone (clotrimazole/betamethasone) should not be used for more than 2 weeks (14 days) for most fungal skin infections in adults, and its use should be limited to the shortest time possible to achieve treatment goals. The medication contains betamethasone, a potent topical steroid, which can cause skin thinning, stretch marks, and increased absorption of the steroid into the bloodstream when used for extended periods 1. For certain body areas like the face, groin, or armpit, usage should be limited to 7 days due to higher absorption risks. If symptoms persist after the recommended treatment period, patients should consult their healthcare provider rather than continuing use. The clotrimazole component treats the fungal infection while the betamethasone reduces inflammation and itching, but the steroid component makes this medication unsuitable for long-term use.
Key Considerations
- The use of combination antifungal/corticosteroid preparations like Lotrisone has been criticized for being less effective and more expensive than antifungal monotherapy, with a higher risk of adverse cutaneous reactions 1.
- Topical corticosteroids like betamethasone can increase susceptibility to bacterial and fungal infections, and may preclude their use when infection is the known cause of the disease 2.
- Children may be more vulnerable than adults to systemic effects of topical corticosteroids due to proportionately greater percutaneous absorption 2.
- The use of combination clotrimazole 1% cream/betamethasone diproprionate 0.05% cream (Lotrisone) for the treatment of tinea corporis may be associated with persistent/recurrent infection 3.
Recommendations
- Use Lotrisone for the shortest time possible to achieve treatment goals.
- Limit usage to 2 weeks (14 days) for most fungal skin infections in adults.
- Limit usage to 7 days for certain body areas like the face, groin, or armpit.
- Consult a healthcare provider if symptoms persist after the recommended treatment period.