What are the available strengths of Clotrimazole (antifungal medication)?

From the Guidelines

Clotrimazole is available in 1% and 2% strengths for vaginal use, as indicated in the most recent guidelines 1. The available strengths of Clotrimazole for vaginal use are 1% and 2% creams, with the 1% cream applied intravaginally daily for 7–14 days and the 2% cream applied intravaginally daily for 3 days, as recommended in the 2021 Centers for Disease Control and Prevention guidelines 1. Some key points to consider when using Clotrimazole include:

• The strength and formulation of Clotrimazole depend on the type and severity of the fungal infection being treated.
• For vaginal yeast infections, Clotrimazole can be used as a 1% or 2% cream, with the specific regimen depending on the severity of the infection and the patient's response to treatment.
• It is essential to complete the full course of treatment, even if symptoms improve, to prevent recurrence of the infection.
• Clotrimazole works by disrupting the fungal cell membrane, preventing the fungus from growing and reproducing.
• The most recent guidelines should always be consulted for the latest recommendations on the use of Clotrimazole and other antifungal medications 1.

From the FDA Drug Label

PRINCIPAL DISPLAY PANEL - 21 g Tube Carton TopCare® NDC 36800-062-00 3-DAY TREATMENT Clotrimazole 3 CLOTRIMAZOLE VAGINAL CREAM USP (2%) The available strength of Clotrimazole is 2% 2.

From the Research

Clotrimazole Strengths

• Clotrimazole is available in various strengths, including:
  • 1% cream, as mentioned in the studies 3, 4, 5
  • 2% cream, as mentioned in the study 6
  • 10% cream, as mentioned in the study 6
• These strengths are used to treat different types of fungal infections, such as:
  • Dermatophytosis of the skin
  • Vaginal candidosis
  • Superficial fungal cutaneous infection in intertriginous areas
• The choice of strength and formulation (e.g., cream, powder) may depend on the specific infection being treated and the patient's individual needs.

Formulations and Concentrations

• Clotrimazole is available in different formulations, including:
  • Creams
  • Powders
  • Vaginal tablets
• The concentrations of clotrimazole in these formulations can vary, ranging from 1% to 10%.
• For example, a study compared the efficacy of 1% clotrimazole cream with 1% clotrimazole powder in patients with superficial fungal cutaneous infection in intertriginous areas 5.