What is the typical starting dose of Vyvanse (lisdexamfetamine) for adults and children with Attention Deficit Hyperactivity Disorder (ADHD)?

From the Guidelines

The typical starting dose of Vyvanse (lisdexamfetamine) for adults and children with Attention Deficit Hyperactivity Disorder (ADHD) is not explicitly stated in the provided evidence, but based on the general guidelines for stimulant medications, adults or older adolescents may be started on doses of 5 mg of MPH, DEX, or AMP, with titration upward in 5- to 10-mg intervals each week until symptoms are controlled 1. However, it's essential to note that the provided evidence does not specifically mention Vyvanse (lisdexamfetamine) but rather discusses the use of stimulant medications such as methylphenidate (MPH), dextroamphetamine (DEX), and mixed-salts amphetamine (AMP) in the treatment of ADHD. Some key points to consider when initiating treatment with stimulant medications like Vyvanse include:

• Starting with a low dose and gradually increasing it in weekly increments until symptoms are controlled
• Monitoring patients for signs of tolerance and side effects such as weight loss, blood pressure increase, or agitation
• Adjusting the dose based on individual needs and response to treatment
• Considering the patient's age, weight, and symptom severity when determining the initial dose and subsequent titration It's crucial to follow the healthcare provider's specific dosing instructions and to prioritize the patient's safety and well-being when initiating treatment with stimulant medications like Vyvanse 1.

From the FDA Drug Label

The recommended starting dosage in adults and pediatric patients 6 years and older is 30 mg once daily in the morning. The typical starting dose of Vyvanse (lisdexamfetamine) for adults and children with Attention Deficit Hyperactivity Disorder (ADHD) is 30 mg once daily in the morning.

• The dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to a maximum recommended dosage of 70 mg once daily 2.
• It is essential to follow the recommended dosage and administration guidelines to ensure safe and effective treatment.
• Patients should be closely monitored for signs and symptoms of abuse, misuse, and addiction, as well as other potential side effects.

From the Research

Typical Starting Dose of Vyvanse for Adults and Children with ADHD

• The typical starting dose of Vyvanse (lisdexamfetamine) for adults with Attention Deficit Hyperactivity Disorder (ADHD) is 30 mg once daily in the morning 3.
• For children and adolescents, the recommended starting dose is 30 mg once daily, with the option to increase the dose in increments of 10-20 mg at weekly intervals until the optimal dose is reached 4.
• The maximum recommended dose for adults is 70 mg per day, while for children and adolescents, the maximum dose is 70 mg per day for those 6 years and older, and 50-70 mg per day for those 13-17 years old 5, 4.

Dosing Considerations

• The dose of Vyvanse should be individualized according to the patient's response and tolerance 3.
• Patients who have not had an adequate response to other stimulant medications may require higher doses of Vyvanse 5.
• The safety and efficacy of Vyvanse have been established in clinical trials for the treatment of ADHD in adults and children, with a safety profile consistent with other long-acting stimulants 3, 4.

Pharmacokinetics and Metabolism

• Vyvanse is a prodrug that is converted to its active form, d-amphetamine, after administration 6.
• The absorption, metabolism, and elimination of Vyvanse have been studied in healthy adult volunteers, with results showing that the drug is quickly absorbed, extensively metabolized, and rapidly eliminated 6.