From the Research
Consuming 2 beers per day can cause macrocytosis, which is an enlargement of red blood cells, as regular alcohol consumption at this level can interfere with folate metabolism and directly affect bone marrow, leading to the production of larger red blood cells. This condition is often detected through routine blood work showing an elevated mean corpuscular volume (MCV) above 100 fL. According to a study published in 2014 1, macrocytosis and macrocytic anemia were found in 62.4 and 24.1% of Japanese alcoholic men, respectively. The study suggests that the erythrocyte abnormalities in alcoholics are attributable to high acetaldehyde exposure as well as to nutritional deficiencies and may be prevented by folate.
Some key points to consider:
- Alcohol-induced macrocytosis can occur even without clinical signs of liver disease or malnutrition 2
- The effect is dose-dependent, and daily consumption of 2 beers (approximately 24-28 grams of alcohol) is sufficient to cause this change in some individuals 1
- Macrocytosis may develop after just 4-8 weeks of regular alcohol consumption
- Reducing or eliminating alcohol intake is recommended if you're experiencing macrocytosis and consume alcohol regularly
- Supplementing with B vitamins, particularly folate and B12, may help address nutritional deficiencies that contribute to macrocytosis, though addressing the underlying cause—alcohol consumption—is most important 1
It's essential to note that the relationship between alcohol consumption and macrocytosis is well-established, and reducing alcohol intake is a crucial step in managing this condition. As stated in a study published in 2009 3, alcoholism is one of the most common etiologies of macrocytosis, along with vitamin B12 and folate deficiencies, and medications.