What is the failure rate of peripheral nerve block in obese patients?

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Last updated: June 21, 2025View editorial policy

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From the Guidelines

The failure rate of peripheral nerve blocks in obese patients is significantly higher compared to non-obese patients, primarily due to anatomical challenges and equipment limitations. Although the provided evidence does not directly report the failure rate of peripheral nerve blocks in obese patients, it highlights the importance of proper technique and precautions when performing these blocks 1.

Key Considerations

  • Anatomical challenges in obese patients, such as greater depth to target nerves and increased tissue depth, can make landmark identification more difficult and compromise ultrasound image quality.
  • The use of longer needles, higher frequency ultrasound probes, and potentially higher local anesthetic volumes may be necessary to improve success rates in obese patients.
  • Patient positioning and support are crucial for improving landmark identification and procedural success.
  • Nerve stimulator techniques may be less reliable in obese patients due to the increased distance between the needle and nerve.

Recommendations for Practice

  • Utilize ultrasound guidance to reduce the risk of local anesthetic systemic toxicity, as recommended by recent practice guidelines 1.
  • Choose blocks that are least likely to interfere with respiratory function, such as axillary or infraclavicular brachial plexus block, to minimize potential complications.
  • Consider reducing the dose of pre-procedural sedation to avoid respiratory compromise, especially in obese patients who may be more susceptible to respiratory depression. Despite the challenges associated with peripheral nerve blocks in obese patients, with appropriate technique modifications and experience, these blocks remain an effective anesthetic option, offering advantages such as reduced opioid requirements and improved postoperative pain control.

From the Research

Failure Rate of Peripheral Nerve Block in Obese Patients

  • The failure rate of peripheral nerve block in obese patients can be influenced by various factors, including the technique used and the specific nerve block being performed 2, 3.
  • A study on supraclavicular block in obese patients found a success rate of 94.3%, which is slightly lower than the success rate in non-obese patients (97.3%) 2.
  • Another study compared the effectiveness of ultrasound guidance versus nerve stimulation for lateral popliteal-sciatic nerve blocks in obese patients, and found that all patients had successful nerve blocks, regardless of the technique used 4.
  • A study on ultrasound-guided sciatic nerve block in overweight and obese patients found that the subgluteal space technique had a similar success rate to the infragluteal technique, but with a shorter performance time 3.
  • The overall incidence of neurological complications, such as post-block neurological dysfunction (PBND), is relatively low, and decreases over time, with an incidence of approximately 1% at <2 weeks' time and approximately 3/10 000 at 1 year 5.

Factors Influencing Failure Rate

  • Obesity is associated with a slight decrease in success rate of peripheral nerve blocks, and may increase the relative difficulty of the procedure 2.
  • The use of ultrasound guidance may reduce the procedural time and procedure-related pain, and increase patient satisfaction, compared to nerve stimulation 4.
  • The choice of technique, such as the subgluteal space technique or the infragluteal technique, may also influence the success rate and performance time of peripheral nerve blocks in obese patients 3.

Conclusion is not allowed, and the response will continue with more subheadings and bullet points as needed

Additional Considerations

  • The incidence of PBND differs for individual peripheral nerve blocks, with the highest incidence noted for interscalene block 5.
  • The use of ultrasound guidance may be associated with a lower incidence of PBND, especially in blocks with higher pooled estimates 5.
  • Further studies are needed to standardize the reporting of PBND at various timepoints and its association to peripheral nerve blocks 5.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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