There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the Research
Overview of Current Vaccines
- Not all current vaccines are made with Messenger RNA (mRNA) 1, 2, 3, 4, 5.
- mRNA vaccines have been shown to be effective and safe in combating COVID-19 and other infectious diseases 1, 2, 3, 4, 5.
Types of Vaccines
- There are different types of vaccines, including conventional messenger RNA (mRNA) vaccines, circular RNA (circRNA) vaccines, and self-amplifying RNA (saRNA) vaccines 2, 3.
- mRNA vaccines have been used to combat COVID-19 and have shown high efficacy and safety profiles 3, 5.
Development and Challenges
- The development of mRNA vaccines has faced several challenges, including mRNA instability, limited duration of antibody response, and high research expenses 2, 3.
- Despite these challenges, mRNA vaccines have been shown to be a promising tool in the fight against infectious diseases and have the potential to be used against other diseases, such as cancer and inherited diseases 1, 3, 4.
Examples of mRNA Vaccines
- Two out of the four most widely applied vaccines against COVID-19 are based on the mRNA platform 1.
- The first two vaccines against COVID-19 to receive accelerated regulatory authorization were nucleoside-modified mRNA vaccines, which showed more than 90% protective efficacy against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection 3.