What is the diagnosis of a red, swollen left lower extremity (leg)?

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Last updated: February 26, 2025View editorial policy

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Differential Diagnosis for Red Swollen Left Leg

  • Single Most Likely Diagnosis
    • Cellulitis: This is the most common cause of a red, swollen leg, typically resulting from a bacterial infection of the skin and soft tissues. It is often accompanied by warmth, pain, and sometimes fever.
  • Other Likely Diagnoses
    • Deep Vein Thrombosis (DVT): A blood clot in the deep veins of the leg can cause swelling, redness, and warmth. Risk factors include recent surgery, immobility, cancer, and genetic predispositions.
    • Phlebitis: Inflammation of a vein, which can be superficial or deep, leading to redness, swelling, and warmth along the path of the vein.
    • Eczema or Dermatitis: Skin conditions that can cause redness and swelling, especially if there is an allergic reaction or irritation.
    • Insect Bite or Sting: Certain insect bites or stings can cause localized redness and swelling.
  • Do Not Miss Diagnoses
    • Necrotizing Fasciitis: A severe infection that destroys tissue under the skin, requiring immediate medical attention. It presents with severe pain, swelling, and redness, often with a feeling of the skin being tight.
    • Compartment Syndrome: Increased pressure within a muscle compartment, which can lead to muscle and nerve damage. Symptoms include severe pain, especially on stretching the muscle, and swelling.
    • Pulmonary Embolism (if DVT is suspected): A blood clot that breaks loose and travels to the lungs, which can be life-threatening.
  • Rare Diagnoses
    • Erythema Nodosum: An inflammatory condition characterized by the sudden formation of painful, red lumps on the skin, often on the legs.
    • Lymphedema: Swelling caused by impaired lymph drainage, which can be primary (genetic) or secondary (due to surgery, infection, etc.).
    • Panniculitis: Inflammation of the subcutaneous fat, which can cause redness, swelling, and pain in the affected area.
    • Vasculitis: Inflammation of the blood vessels, which can cause a variety of symptoms including redness and swelling of the legs, depending on the vessels affected.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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