From the Research
A single 100mg dose of vitamin B6 (pyridoxine) typically has effects that last approximately 8-12 hours in the body. After oral administration, vitamin B6 is rapidly absorbed from the gastrointestinal tract, with peak blood levels occurring within 1-2 hours 1. The body then converts it to its active form, pyridoxal 5'-phosphate, which participates in numerous enzymatic reactions. While the immediate physiological effects may last less than a day, the vitamin is partially stored in the liver, muscles, and brain, providing some residual benefit. However, as a water-soluble vitamin, excess amounts are excreted through urine rather than stored extensively. For ongoing benefits, regular intake is necessary. It's worth noting that 100mg exceeds the Recommended Dietary Allowance (1.3-1.7mg for adults), but is within the range commonly used for supplementation. If you're taking B6 for a specific condition, consistent daily dosing may be more effective than a single dose, though you should consult a healthcare provider before starting any supplement regimen, especially at doses above 100mg daily which could potentially cause nerve damage with long-term use 2.
Some key points to consider:
- The effects of vitamin B6 can last for several hours, but regular intake is necessary for ongoing benefits
- Vitamin B6 is rapidly absorbed and converted to its active form, pyridoxal 5'-phosphate
- Excess amounts of vitamin B6 are excreted through urine, rather than stored extensively
- High doses of vitamin B6 can cause nerve damage with long-term use, so it's essential to consult a healthcare provider before starting any supplement regimen
- The recommended daily allowance for vitamin B6 is 1.3-1.7mg for adults, but 100mg is within the range commonly used for supplementation 3.
It's also important to note that vitamin B6 supplements are preferred over pyridoxine supplements due to minimal neurotoxicity observed in neuronal cell viability tests 1. Additionally, weekly administration of vitamin B6 is preferred over daily use to prevent toxicity, as B6 metabolites have a long half-life 1.