How to manage a seroma complicating an anterior total hip replacement?

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Last updated: June 22, 2025View editorial policy

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From the Research

Management of a seroma complicating an anterior total hip replacement requires a stepwise approach based on severity, with the most recent and highest quality study suggesting that aspiration under sterile conditions and possible injection of a sclerosing agent like doxycycline may be effective in resolving the seroma 1.

Key Considerations

  • For small, asymptomatic seromas, conservative management is recommended with observation, rest, compression garments, and regular monitoring.
  • For larger or symptomatic seromas, aspiration under sterile conditions may be necessary, typically using an 18-gauge needle after local anesthetic administration.
  • If the seroma recurs after 2-3 aspirations, more definitive treatment is warranted, which may include ultrasound-guided drainage with placement of a small drain for 24-48 hours, or surgical intervention with incision, drainage, and possible capsule excision.

Prophylactic Measures

  • Meticulous surgical technique
  • Careful hemostasis
  • Consideration of closed-suction drains during initial surgery
  • Appropriate postoperative compression

Monitoring for Infection

  • Increasing pain
  • Redness
  • Warmth
  • Fever
  • Immediate evaluation for possible infected hematoma or deep infection is necessary if signs of infection are present.

Recent Study Findings

  • A 2021 study published in BMJ case reports found that aspiration and injection of doxycycline was effective in resolving a seroma complicating a total hip replacement 1.
  • Another study published in 2020 found that vacuum-assisted closure therapy was effective in managing chronic seromas 2.
  • However, the most recent and highest quality study 1 suggests that aspiration and injection of a sclerosing agent may be a more effective treatment option for seromas complicating anterior total hip replacement.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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