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From the Research
Relationship between GLP-1 analogues and Parkinson's disease
- The relationship between Glucagon-like peptide-1 (GLP-1) analogues and Parkinson's disease is an area of ongoing research, with studies suggesting that GLP-1 receptor agonists may have neuroprotective effects in Parkinson's disease 1, 2, 3, 4, 5.
- GLP-1 analogues, such as exenatide and liraglutide, have been shown to improve motor impairment and cognitive function in patients with Parkinson's disease, and may have a disease-modifying effect 2, 4.
- The mechanisms of action of GLP-1 analogues in Parkinson's disease are not fully understood, but may involve inhibition of inflammation, improvement of neuronal survival, and maintenance of synapses and dopaminergic transmission in the brain 1, 2, 3.
- Clinical trials have reported impressive effects of GLP-1 analogues in patients with Parkinson's disease, including improved motor function and cognitive function, and reduced risk of serious adverse events 2, 4.
- Dual GLP-1/GIP receptor agonists, which can penetrate the blood-brain barrier, have been developed and may have superior effects in animal models of Parkinson's disease compared to GLP-1 drugs alone 2.
Key findings
- GLP-1 receptor agonists may improve motor impairment and cognitive function in patients with Parkinson's disease 1, 2, 4.
- GLP-1 analogues may have a disease-modifying effect in Parkinson's disease, with improvements in motor function persisting for some time after cessation of treatment 4.
- The effectiveness of GLP-1 receptor agonists for improving health-related quality of life, non-motor outcomes, and psychological outcomes in Parkinson's disease is unclear, and further research is needed 4.
- GLP-1 receptor agonists may have neuroprotective effects in animal models of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease 1, 2, 3, 5.