Is it possible to buy 0.5% testosterone gel concentration?

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Last updated: June 22, 2025View editorial policy

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From the Guidelines

Yes, it is possible to buy 0.5% testosterone gel concentration, although it may be less commonly prescribed than the standard 1% or 1.62% formulations 1. This lower concentration is available by prescription and is typically marketed under brand names or as generic testosterone gel 0.5%. The 0.5% gel is applied topically, usually once daily to clean, dry skin on the shoulders, upper arms, or abdomen.

Key Considerations

  • When using testosterone gel, it's essential to wash hands thoroughly after application and allow the gel to dry completely before dressing to prevent transfer to others.
  • The area should be covered with clothing after the gel dries.
  • This lower concentration delivers less testosterone per application, which may help reduce the risk of side effects like skin irritation, acne, or unwanted hormonal effects while still providing therapeutic benefits for conditions like hypogonadism.

Administration and Monitoring

  • Testosterone levels should be tested 2 to 3 months after treatment initiation, and/or after any dose change 1.
  • Once stable levels are confirmed on a given dose, monitoring every 6 to 12 months is typically sufficient.
  • For patients receiving transdermal preparations, levels can be measured at any time, with the understanding that peak values occur 6 to 8 hours after application of the patch, and that testosterone concentrations can vary substantially with gel use, although not in a predictable way 1.

From the Research

Availability of 0.5% Testosterone Gel Concentration

  • The provided studies do not specifically mention the availability of 0.5% testosterone gel concentration 2, 3, 4, 5, 6.
  • However, the studies discuss various formulations and concentrations of testosterone replacement therapy, including transdermal gels 2, 5.
  • The choice of formulation and concentration depends on factors such as cost, patient preference, and individual needs 5, 6.
  • It is possible that 0.5% testosterone gel concentration may be available, but it is not explicitly mentioned in the provided studies.
  • Patients should consult with their healthcare provider to determine the best course of treatment and to discuss the availability of specific formulations and concentrations 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Transdermal testosterone replacement therapy in men.

Drug design, development and therapy, 2014

Research

Current status of testosterone replacement therapy in men.

Archives of family medicine, 1999

Research

Testosterone replacement therapy.

Andrology, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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